Cyclic amine derivatives and use thereof

A composition for use as an antiobestic agent containing a compound of the formula (II):

• wherein B is
• wherein R1, R2 and R3 are each independently hydrogen, halogen, hydroxy, lower alkyl, halogenated lower alkyl, lower alkoxy, halogenated lower alkoxy, carboxy lower alkoxy, optionally substituted phenyl, optionally substituted phenoxy, or optionally substituted phenyl (lower) alkoxy, wherein said optional substitution is with one to three members selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkylthio, hydroxy, amino, carboxy, cyano, nitro, lower alkylcarbonyl, lower alkoxycarbonyl, halogenated lower alkyl, halogenated lower alkoxy, carboxy (lower) alkoxy, optionally substituted phenyl, optionally substituted phenloxy, and optionally substituted phenyl (lower) alkoxy, wherein the latter optional substitution is lower alkyl, halogen, halogenated lower alkyl and halogenated lower alkoxy;
• Z1 is CH;
• X is O;
• m is 0;
• n is an integer of 1 to 5;
• p is 2,
• provided that the following (1) and (2) are excluded:
• (1) n is 2 and B is 3,4-dimethylphenyl, 4-t-butylphenyl, 4-(t-butyl-CH2C(CH3)2)-phenyl, 4-isopentylphenyl, 2-isopropyl-5-methylphenyl, 3-methoxyphenyl or 2-Cl, 4-Br-phenyl, (2) n is 3 and B is 2,6-dimethylphenyl, and pharmaceutically acceptable salt, or hydrate thereof and a pharmaceutically acceptable carrier.