Substituted amidoalkyl-uracils and their use

A compound of the formula (I)

• in which
• A represents a ring member selected from the group consisting of:
• —D—,
• —CH2—D—,
• —D—CH2—,
• —CH═CH—CH2—,
• —CH2—CH═CH—,
• —CH2—CH2—D—,
• —D—CH2—CH2 and
• —CH2—D—CH2—, in which
• D represents —CH2—, —O— or —S—,
• X represents (C2-C10)-alkylene or (C3-C8)-cycloalkylene which are optionally mono- or polysubstituted, independently of one another, by substituents selected from the group consisting of (C1-C6)-alkoxy, hydroxyl, amino, mono- and di-(C1-C6)-alkylamino and oxo,
• R1 represents hydrogen, (C1-C6)-alkyl which is optionally mono- or polysubstituted by halogen, or represents (C3-C8)-cycloalkyl,
• R2 represents a group of the formula —SO2—R4, —SO2—NR5R6, —CO—R7, —CO—NR8R9 or —CO—OR10, in which
• R4 represents (C1-C6)-alkyl or (C3-C8)-cycloalkyl which are optionally substituted by (C1-C4)-alkoxy, (C6-C10)-aryl, 5- to 10-membered heteroaryl having up to 4 heteroatoms from the group consisting of N, O and/or S, or up to trisubstituted by halogen, where the aryl or heteroaryl radicals for their part are optionally substituted by hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl, halogen, cyano or nitro, or represents a group of the formula
• —G—E
• in which
• E represents (C6-C10)-aryl or a 5- to 13-membered saturated, partially unsaturated or aromatic heterocycle having up to four heteroatoms from the group consisting of N, O and S, where the ring systems are in each case optionally substituted up to five times by identical or different substituents selected from the group consisting of nitro, cyano, halogen, optionally benzamido-substituted (C1-C6)-alkyl, trifluoromethyl, (C3-C6)-cycloalkyl, hydroxyl, oxo, (C1-C6)-alkoxy, carboxyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkanoyl, amino, aminocarbonyl, mono- and di-(C1-C6)-alkylaminocarbonyl, (C1-C6)-alkanoylamino, (C1-C6)-alkylsulphonyl, (C1-C6)-alkylthio, optionally (C1-C4)-alkyl-, halogen- or nitro-substituted phenylsulphonyl,
• and
• G is absent or represents (C6-C10)-arylene or 5- to 10-membered heteroarylene having up to 4 heteroatoms from the group consisting of N, O and S, which are in each case optionally substituted up to three times by identical or different substituents selected from the group consisting of nitro, cyano, halogen, (C1-C6)-alkyl, trifluoromethyl, (C3-C6)-cycloalkyl, hydroxyl, (C1-C6)-alkoxy, carboxyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkanoyl, amino, aminocarbonyl, mono- and di-(C1-C6)-alkylaminocarbonyl, (C1-C6)-alkanoylamino, (C1-C6)-alkylsulphonyl and (C1-C6)-alkylthio,
• R5 and R6 independently of one another each represent hydrogen, (C3-C8)-cycloalkyl, (C1-C6)-alkyl, (C6-C10)-aryl or 5- to 10-membered heteroaryl which, independently of one another, are in each case optionally substituted by (C1-C4)-alkoxy, hydroxyl, cyano, carboxyl, (C1-C4)-alkoxycarbonyl, up to three times by halogen, by (C6-C10)-aryl or by 5- to 10-membered heteroaryl, where the aryl and hetaryl radicals for their part are optionally substituted by hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl, halogen, cyano or nitro, or
• R5 and R6 together with the nitrogen atom to which they are attached form a saturated 3- to 7-membered heterocycle in which optionally one carbon ring member is replaced by a further heteroatom from the group consisting of nitrogen, oxygen and sulphur and which is optionally substituted by (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, oxo, carboxyl or (C1-C4)-alkoxycarbonyl,
• R7 represents (C1-C6)-alkyl or (C3-C8)-cycloalkyl which are optionally substituted by (C1-C4)-alkoxy, (C6-C10)-aryl, 5- to 10-membered heteroaryl having up to 4 heteroatoms from the group consisting of N, O and S or up to three times by halogen, where the aryl or heteroaryl radicals for their part are optionally substituted by hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl, halogen, cyano or nitro, or represents a group of the formula
• —G—E
• in which
• E represents (C6-C10)-aryl or a 5- to 13-membered saturated, partially unsaturated or aromatic heterocycle having up to four heteroatoms from the group consisting of N, O and S, where the ring systems are in each case optionally substituted up to five times by identical or different substituents selected from the group consisting of nitro, cyano, halogen, optionally benzamido-substituted (C1-C6)-alkyl, trifluoromethyl, (C3-C6)-cycloalkyl, hydroxyl, oxo, (C1-C6)-alkoxy, carboxyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkanoyl, amino, aminocarbonyl, mono- and di-(C1-C6)-alkylaminocarbonyl, (C1-C6)-alkanoylamino, (C1-C6)-alkylsulphonyl, (C1-C6)-alkylthio and optionally (C1-C4)-alkyl-, halogen- or nitro-substituted phenylsulphonyl, and
• G is absent or represents (C6-C10)-arylene or 5- to 10-membered heteroarylene having up to 4 heteroatoms from the group consisting of N, O and S, which are in each case optionally substituted up to three times by identical or different substituents selected from the group consisting of nitro, cyano, halogen, (C1-C6)-alkyl, trifluoromethyl, (C3-C6)-cycloalkyl, hydroxyl, (C1-C6)-alkoxy, carboxyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkanoyl, amino, aminocarbonyl, mono- and di-(C1-C6)-alkylaminocarbonyl, (C1-C6)-alkanoylamino, (C1-C6)-alkylsulphonyl and (C1-C6)-alkylthio,
• R8 and R9 independently of one another each represent hydrogen, (C3-C8)-cycloalkyl or (C1-C6)-alkyl which are in each case optionally substituted by (C1-C4)-alkoxy, hydroxyl, cyano, carboxyl, (C1-C4)-alkoxycarbonyl, up to three times by halogen, by (C6-C10)-aryl or by 5- to 10-membered heteroaryl, where the aryl and hetaryl radicals for their part are optionally substituted by hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl, halogen, cyano or nitro, or
• R8 and R9 together with the nitrogen atom to which they are attached form a saturated 3- to 7-membered heterocycle in which optionally one carbon ring member is replaced by a further heteroatom from the group consisting of nitrogen, oxygen and sulphur and which is optionally substituted by (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, oxo, carboxyl or (C1-C4)-alkoxycarbonyl,
• R10 represents (C1-C6)-alkyl, (C3-C8)-cycloalkyl or (C6-C10)-aryl which are optionally mono- or polysubstituted by hydroxyl, (C1-C4)-alkoxy, halogen, cyano or nitro, or
• R1 and R2 together with the nitrogen atom to which they are attached form a saturated 5- to 10-membered mono- or bicyclic heterocycle,
• which has a carbonyl or sulphonyl group directly adjacent to the nitrogen atom to which R1 and R2 are attached,
• in which optionally up to two carbon ring members are replaced by oxygen and/or sulphur and
• which is optionally substituted up to three times by identical or different substituents selected from the group consisting of (C1-C6)-alkyl, hydroxyl, oxo, (C1-C6)-alkoxy, carboxyl, (C1-C4)-alkoxycarbonyl and halogen, and
• R3 represents hydrogen or (C1-C6)-alkoxycarbonyl
• or a pharmaceutically acceptable salt or hydrate thereof.