2-oxo-1, 4-benzoxazine compounds for treatment of tuberculosis
AssigneeUniversity of Central Florida
InventorsD. Howard Miles, Krasnykh Olga Petrovna, Saleh Naser, Solodnikov Sergey Yurjevich, Elena A. Goun, Suslonov Vladimir Michailovich
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Abstract
Compounds belonging to novel classes of 2-oxo-1,4-benzoxazine heterocyclic compounds and their close derivatives, are disclosed along with the surprising use property of these compounds as bacteriostatic agents for humans and non-humans against mycobacteria. These species include: 4-benzoyl-3-benzoyloxy-2-(2-oxo-2H-1,4-benzoxazin-3-yl)pyrido[2,1-c][1,4]benzoxazin-1,5-dione; and, 2,4,6-trimethylphenyl 2-(3,4-dihydro-2-oxo-2H-1,4-benzoxazin-3-ylidene)-3-p-methoxyphenyl-3-oxo-propanoate.
Claims7
A class of heterocyclics having the property of bacteriostatic agent activity against mycobacteria comprising 2-oxo-1,4-benzoxazine heterocyclics having the structural formula indicated by:
- R1=H or CH3
- R2=aryl.
Dependencies are inferred from the claim text.