Benzimidazole derivatives and pharmaceutical compositions comprising these compounds

A benzimidazole derivative represented by Formula I,

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R′ represents a group of the formula -(alk)q-R1, in which (alk) represents alkyl, alkenyl, or alkynyl, q is 0 or 1, and R1 represents a group of the formula —CO2R2, wherein R2 represents hydroxy-alkyl, alkoxy-alkyl, or thioalkoxy-alkyl;
• and
• R″ represents a group of the formula
• in which formula “o” is 0 or 1, “n” is 0, 1, or 2, X represents N or CR, Y represents O, NR11, or CHR11, wherein R11 represents hydrogen, alkyl, hydroxyalkyl, alkoxy-alkyl, carboxyl, or acyl, or a group of the formula -(alkyl)p-CN, -(alkyl)p-aryl, -(alkyl)p-O-aryl, -(alkyl)p-O-aralkyl, -(alkyl)p-“Heterocycle”, -(alkyl)p-CO2-“Heterocycle”, or -(alkyl-CO2)p-(alkyl)t-COR5, wherein p, s, and t independently of each another is 0 or 1, “Heterocycle” represents a mono- or polycyclic heterocyclic group, which heterocyclic group is optionally substituted one or more times with substituents selected from the group consisting of halogen, alkyl, hydroxy, oxo, cyano, hydroxy-alkyl, alkoxy—alkyl, carboxyl, and acyl, R5 represents hydroxy, alkoxy, hydroxy-alkoxy, alkoxy—alkoxy, thioalkoxy-alkoxy, aryl, or aralkyl, or a group of the formula —NR6R7 or -O-alkyl-NR6R7, in which formulas R6 and R7 independently of each another represent hydrogen, alkyl, cycloalkyl, or a mono- or polycyclic heterocyclic group, which heterocyclic group is optionally substituted one or more times with substituents selected from the group consisting of alkyl and acyl, or R6 and R7 together with the nitrogen to which they are attached form a mono- or polycyclic heterocyclic group, which heterocyclic group is optionally substituted one or more times with substituents selected from the group consisting of alkyl and acyl, and R14 and R15 independently of each another represent hydrogen, alkyl, hydroxy-alkyl, alkoxy-alkyl, carboxyl, or acyl.