Treatment of tension-type headaches with NMDA receptor antagonists
AssigneeHead Explorer A/S
InventorsJes Olesen, Lars Bendtsen, Rigmor Jensen, Ulf Madsen
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Abstract
NMDA receptor antagonists, especially mirtazapine, can be used to treat tension-type headaches.
Claims51
A method for treatment of a tension-type headache in a person in need of such treatment, comprising administering an amount of an agent effective to interact with neuronal transmission connected with pain perception, so as to prevent or reduce central sensitization, which agent comprises an NMDA glutamate receptor antagonist or a prodrug thereof, with the proviso that said antagonist is not ethyl 2-amino-6-(4-fluorobeznylamino)-3-pyridylcarbamate, an arylglycinamide derivative as defined herein or amitriptyline.
A method for treatment of tension-type headache in a person in need of such treatment, comprising administering an amount of an agent which, in the peripheral and/or central nervous system, is effective to specifically interact with neuronal transmission connected with pain perception by
- substantially antagonizing the action of glutamate on the NMDA receptor,
- with the proviso that said agent is not ethyl 2-amino-6-(4-fluorobenzylamino)-3-pyridylcarbamate, an arylglycinamide derivative as defined herein, or amitriptyline.
A method for treatment of a tension-type headache in a person in need of such treatment, comprising administering to said person a therapeutically effective amount of mirtazapine or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.