Substituted pyridone compounds and methods of use

A compound of formula

• or a pharmaceutically acceptable salt thereof, wherein
• X is O, S or NR5;
• provided that the combined total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals in —VC(R)W— is 0-3;
• U is NR21 or CHR21;
• and n is an integer of 1-3;
• wherein each R5 is independently
• (1) hydrogen radicals;
• (2) alkyl, alkenyl or alkynyl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, hydroxy, alkoxy, alkylthio, cyano or halo;
• or
• (3) aryl, heteroaryl, aralkyl, heteroaralkyl, heterocyclyl, heterocyclylalkyl, cycloalkyl or cycloalkylalkyl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl;
• and
• wherein each R20 is independently
• (1) alkyl, alkenyl or alkynyl radicals optionally substituted by 1-3 radicals of -CO2R23, amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, N-(alkoxycarbonyl)-N-(alkyl)amino, aminocarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo or aralkoxy, aralkylthio, aralkylsulfonyl, cycloalkyl, heterocyclyl, aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, alkanoyl, alkoxycarbonyl, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo, alkyl or haloalkyl;
• (2) heterocyclyl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, alkoxycarbonyl, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl;
• or
• (3) aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, alkoxycarbonyl, hydroxy, alkoxy, alkylthio, cyano, halo, azido, alkyl or haloalkyl;
• each R21 is independently hydrogen radical or R20;
• each R23 is independently hydrogen or alkyl, or aryl, heteroaryl, aralkyl or heteroaralkyl optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo, alkyl or haloalkyl;
• and
• R11 and R12 are each independently an aryl or heteroaryl radical optionally substituted by 1-3 radicals of
• (1) R30;
• (2) halo or cyano radicals;
• (3) —C(O)—R30, —C(O)—OR29, —C(O)—NR31R32 or —C(NR31)—NR31R32 radicals;
• (4) —OR29, —O—C(O)—R29, —O—C(O)—NR31R32 or —O—C(O)—NR33—S(O)2—R30 radicals;
• (5) —SR29, —S(O)—R30, —S(O)2—R30, —S(O)2—NR31R32, —S(O)2—NR33—C(O)—R30, —S(O)2—NR33—C(O)—OR30 or —S(O)2—NR33—C(O)—NR31R32 radicals;
• or
• (6) —NR31R32, —NR33—C(O)—R29, —NR33—C(O)—OR30, —NR33—C(O)—NR31R32, —NR33—C(NR31)—NR31R32, —NR33—S(O)2—R30 or —NR33—S(O)2—NR31R32 radicals;
• provided that (1) R11 is other than a 4-pyridyl, 4-pyrimidinyl, 4-quinolyl or 6-isoquinolinyl radical optionally substituted by 1-2 substituents;
• and (2) the total number of aryl, heteroaryl, cycloalkyl and heterocyclyl radicals substituted on each of R11 and R12 is 0-1;
• wherein each R30 is independently
• (1) alkyl, alkenyl or alkynyl radicals optionally substituted by 1-3 radicals of —NR31R31, —CO2R23, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo or aralkoxy, aralkylthio, aralkylsulfonyl, heterocyclyl, aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, cyano, halo, alkyl or haloalkyl;
• (2) heterocyclyl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl;
• or
• (3) aryl or heteroaryl radicals optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, halo, alkyl or haloalkyl;
• each R29 is independently hydrogen radical or R30;
• each R31 and R32 are each independently
• (1) hydrogen radicals;
• (2) alkyl radical optionally substituted by an cycloalkyl, aryl, heterocyclyl or heteroaryl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl;
• or
• (3) aryl, heteroaryl, heterocyclyl or cycloalkyl radical optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl;
• and
• wherein each R33 is independently
• (1) hydrogen radical;
• or
• (2) alkyl radical optionally substituted by a radical of heterocyclyl, aryl or heteroaryl optionally substituted by 1-3 radicals of amino, alkylamino, dialkylamino, alkanoylamino, alkoxycarbonylamino, alkylsulfonylamino, hydroxy, alkoxy, alkylthio, cyano, alkyl or haloalkyl.