Modified VEGF Oligonucleotides for Inhibition of tumor growth
AssigneeHybridon, Inc.
InventorsAdrienne P. Smyth, Gregory S. Robinson
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Abstract
Disclosed are oligonucleotides complementary to VEGF-specific nucleic acid useful in reducing the expression of VEGF. Also disclosed are pharmaceutical formulations containing such oligonucleotides useful for treating various disorders associated with neovascularization and angiogenesis.
Claims8
A method of inhibiting vascular endothelial growth factor in tumor cells comprising the step of locally administering to said tumor cells, a therapeutically effective amount of a synthetic oligonucleotide complementary to a human vascular endothelial growth factor target nucleic acid, whereby expression of said vascular endothelial growth factor is inhibited,
- the oligonucleotide having a nucleotide sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, and SEQ ID NO:16.
Dependencies are inferred from the claim text.