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US 6,649,588 B1Granted
Inhibition of TGF-β and uses thereof
AssigneeNorth Shore-Long Island Jewish Research Institute
InventorsSiamak Tabibzadeh, James M. Mason
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AssigneeNorth Shore-Long Island Jewish Research Institute
InventorsSiamak Tabibzadeh, James M. Mason
Estimating the term…
The present invention provides a method for inhibiting activity of TGF-β, comprising contacting tissue expressing TGF-β with an amount of ebaf or an ebaf analogue. The present invention further provides a method for treating a condition associated with overactivity of TGF-β, particularly fibrosis, a defect in cell proliferation, or a coagulation defect. The present invention also provides a method for inhibiting activity of TGF-β, comprising contacting tissue expressing TGF-β with a modulator of ebaf expression, or a modulator of expression of an ebaf analogue. The present invention is further directed to a method for treating fibrosis in a subject in need of treatment, comprising administering to the subject an amount of ebaf or an ebaf analogue effective to treat the fibrosis. Finally, the present invention provides a method for treating a defect in cell proliferation in a subject in need of treatment, comprising administering to the subject an amount of ebaf or an ebaf analogue effective to treat the defect in cell proliferation.
A method for inhibiting activity of TGF-β, comprising bringing tissue expressing TGP-β in direct contact with an amount of an ebaf protein effective to inhibit the activity of TGF-β, wherein the ebaf protein has the amino acid sequence set forth in SEQ ID NO:2.
Dependencies are inferred from the claim text.