Dried blood factor composition comprising trehalose
AssigneeQuadrant Drug Delivery Limited
InventorBruce Joseph Roser
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Abstract
A stable blood factor composition contains a stabilising amount of trehalose in the absence of human serum albumin to provide a product stable at up to 60° C.
Claims3
A method for preparing Factor VIII wherein said Factor VIII is stable at ambient temperatures, wherein said method comprises freeze-drying an aqueous solution of Factor VIII with a stabilizer that consists essentially of trehalose, in the absence of albumin, and wherein the solution contains less than 0.0004 millimoles NaCl per unit of Factor VIII.
A method for preparing Factor VIII wherein said Factor VIII is stable at ambient temperatures, wherein said method comprises freeze-drying an aqueous solution of native Factor VIII with a stabilizer that consists essentially of trehalose, in the absence of albumin, and wherein the solution contains less than 0.0004 millimoles NaCl per unit of Factor VIII.
A method for preparing Factor VIII wherein said Factor VIII is stable at ambient temperatures, wherein said method comprises freeze-drying an aqueous solution of recombinant Factor VIII with a stabilizer that consists essentially of trehalose, in the absence of albumin, and wherein the solution contains less than 0.0004 millimoles NaCl per unit of Factor VIII.
Dependencies are inferred from the claim text.