Isolated nucleic acid molecules encoding human squalene synthase proteins, and related products and processes
AssigneeApplera Corporation
InventorsMing-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
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Abstract
The present invention provides amino acid sequences of human squalene synthase proteins and nucleic acid sequences encoding these squalene synthase proteins. The present invention provides isolated squalene synthase proteins and encoding nucleic acid molecules, vectors and host cells containing these nucleic acid molecules, and processes for producing the squalene synthase proteins.
Claims24
An isolated nucleic acid molecule encoding a squalene synthase, wherein the nucleic acid molecule consists of a nucleotide sequence selected from the group consisting of
- (a) a nucleotide sequence that encodes SEQ ID NO:2, except that residue 45 of SEQ ID NO:2 is arginine;
- (b) a nucleotide sequence that encodes an amino acid sequence having at least 95% sequence identity to SEQ ID NO:2;
- (c) a nucleotide sequence having at least 95% sequence identity to SEQ ID NO:1;
- and
- (d) a nucleotide sequence having at least 95% sequence identity to SEQ ID NO:3.
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a cDNA sequence that encodes SEQ ID NO:2;
- (b) SEQ ID NO:1;
- (c) nucleotides 58-1179 of SEQ ID NO:1;
- and
- (d) a nucleotide sequence that is completely complementary to a nucleotide sequence of any of (a)-(c).
An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence tat encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- (b) a nucleotide sequence consisting of SEQ ID NO:1;
- (c) a nucleotide sequence consisting of SEQ ID NO:3;
- and
- (d) a nucleotide sequence that is completely complementary to a nucleotide sequence of any of (a)-(c).
An isolated polynucleotide consisting of the nucleotide sequence of SEQ ID NO:1.
An isolated polynucleotide consisting of the nucleotide sequence of SEQ ID NO:3.
Dependencies are inferred from the claim text.