Human aggrecanase and nucleic acid compositions encoding the same
AssigneeSyntex (U.S.A.) Inc.
InventorsJohn David Allard, Renu Anand Ileller, Paul Klonowski, Harold Edgar VanWart
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Abstract
Human aggrecanase and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting aggrecanase activity in a host and methods of treating disease conditions associated with aggrecanase activity, e.g. rheumatoid arthritis, osteo-arthritis, infectious arthritis, gouty arthritis, psoriatic arthritis, spondolysis, sports injury, joint trauma, pulmonary disease, fibrosis, and the like.
Claims5
A purified nucleic acid present in other than its natural environment, wherein said nucleic acid comprises a nucleotide sequence encoding an aggrecanase, and wherein the nucleotide sequence has the sequence set forth in SEQ ID NO:01.
Dependencies are inferred from the claim text.