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AssigneeGenVec, Inc.
InventorsDouglas E. Brough, Imre Kovesdi
Estimating the term…
Provided are methods of modulating the persistence of the expression in a cell of a transgene, such as a transgene in a non-Herpes vector or in at least E4Δ adenoviral vector, and related systems. One method comprises contacting the cell with a non-Herpes vector comprising and expressing a gene encoding HSV ICP0, whereupon expression of HSV ICP0 the persistence of expression of the transgene is modulated. Further provided is a system for modulating the persistence of expression of a transgene, which system comprises a non-Herpes vector comprising (i) a gene encoding HSV ICP0 and (ii) a transgene, wherein the HSV ICP0 modulates the persistence of expression of the transgene and either the non-Herpes vector comprises the transgene or the system further comprises a vector, in which case the vector comprises the transgene.
A method of modulating the persistence of expression of a transgene in a cell, wherein the transgene is operably linked to a Rous sarcoma viral promoter or a cytomegaloviral promoter or the transgene is part of an expression cassette that comprises such a promoter, which method comprises contacting the cell with a non-Herpes viral vector comprising and expressing a gene encoding HSV ICP0, whereupon expression of HSV ICP0, the persistence of expression of the transgene is modulated as compared to the persistence of expression of the transgene in the absence of expression of HSV ICP0.
A system for modulating the persistence of expression of a transgene, which system comprises:
Dependencies are inferred from the claim text.