Chlamydia antigens and corresponding DNA fragments and uses thereof
AssigneeAventis Pasteur Limited
InventorsAndrew D. Murdin, Raymond P. Oomen, Pamela L. Dunn
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Abstract
In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequence encoding an 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98 kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.
Claims10
An isolated polynucleotide comprising a polynucleotide from a strain of Chlamydia selected from the group consisting of:
- (a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1;
- and
- (b) a polynucleotide which hybridizes under stringent hybridizing conditions of 6×SSC containing 50% formamide at 42° C. with a polynucleotide that has a complementary sequence to SEQ ID NO:1,
- wherein said isolated polynucleotide, when administered in an immunogenically-effective amount to a mammal, induces a mucosal immune response by said mammal against Chlamydia pneumoniae.
Dependencies are inferred from the claim text.