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US 6,649,353 B2Granted
Method for influencing the p53 linkage to target genes
OwnerWolfgang Willi Deppert, Ella Kiminventors
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Abstract
The invention relates to a method for influencing the p53 binding to a target gene, wherein the conformations of p53 and the target gene are coordinated especially by means of conformation modulators and the binding of p53 can be directly or indirectly detected.
Claims15
A method for identifying a conformation modulator of a p53 target nucleic acid sequence, comprising:
- (a) providing a p53 molecule and a p53 target nucleic acid sequence;
- (b) exposing said p53 molecule and said p53 target nucleic acid sequence to a candidate substance;
- and
- (c) identifying that said candidate substance is a conformation modulator of a p53 target nucleic acid sequence by comparing binding of said p53 molecule to said p53 target nucleic acid sequence in the presence of said candidate substance to binding of said p53 molecule to said p53 target nucleic acid sequence in the absence of said candidate substance.
1 more element
Dependencies are inferred from the claim text.