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US 6,649,347 B2Granted
Use of methylated nucleic acid segments for isolating centromere DNA
AssigneeChromatin, Inc.
InventorsSong Luo, Gregory Copenhaver, Kevin Keith, Daphne Preuss
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Abstract
The invention provides efficient methods for the isolation of centromeres from potentially any organism. The methods may comprise the steps of: a) preparing a first sample of genomic DNA from a selected species; b) obtaining a plurality of methylated nucleic acid segments from the genomic DNA; and c) screening the methylated nucleic acid segments to identify a centromere nucleic acid sequence.
Claims69
A method of obtaining a centromere nucleic acid sequence from a selected organism comprising the steps of
- a) preparing a first sample of genomic DNA from a selected organism;
- b) obtaining a plurality of methylated nucleic acid segments from said genomic DNA;
- and
- c) screening said methylated nucleic acid segments to identify a centromere nucleic acid sequence.
1 more element
Dependencies are inferred from the claim text.