Phenylalanine hydroxylase gene variants, and amino acid and pterin homeostasis, in the definition, detection, treatment and prevention of psychotic, mood and personality disorders
AssigneeNew York State Office of Mental Health
InventorMary Ann Richardson
Life of this patent
Estimating the term…
Abstract
The present invention describes sequence variants in the phenylalanine hydroxylase gene, and biochemical measures of amino acid and pterin homeostasis, which are associated with Psychotic, Mood and Personality Disorders. Methods for the definition of etiological/pathophysiological subtypes of the disorders and for the detection of disorder susceptibility are provided. Treatment and prophylactic strategies targeted at the elaborated psychopathology are also disclosed.
Claims4
A method for treating schizophrenia in a human patient, comprising administering to the human patient an effective amount of a combination of valine, leucine, and isoleucine in the absence of aromatic amino acids.
A method for treating bipolar disorder in a human patient comprising administering to the human patient an effective amount of a combination of valine, leucine, and isoleucine in the absence of aromatic amino acids.
Dependencies are inferred from the claim text.