Methods of reducing β-amyloid polypeptides
AssigneeMayo Foundation for Medical Education and Research
InventorsChristopher B. Eckman, Debra Yager, Sharie Haugabook, Abdul Fauq
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Abstract
The invention features methods of reducing the level of a β-amyloid (Aβ) polypeptide using an Cimicifuga extract. The invention also features methods of producing an active fraction from an extract of Cimicifuga. The invention further features a composition containing an active fraction of a Cimicifuga extract and an article of manufacture containing such a composition.
Claims23
A method of reducing the level of a β-amyloid (Aβ) polypeptide in or secreted from a cell in vitro, said method comprising contacting said cell with an amount of a Cimicifuga extract or of an active fraction thereof effective for reducing the level of said Aβ polypeptide in or secreted from said cell and monitoring the level of said Aβ polypeptide in or secreted from said cell.
A method for reducing the level of an Aβ polypeptide in a mammal in need thereof, said method comprising administering an amount of a Cimicifuga extract or an active fraction thereof to said mammal effective for reducing the level of said Aβ polypeptide and monitoring the level of said Aβ polypeptide in said mammal.
Dependencies are inferred from the claim text.