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AssigneeUniversidade De Santiago De Compostela
InventorsMaria Jose Alonso Fernandez, Pilar Calvo Salve, Carmen Remunan Lopez, Jose Luis Vila Jato
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Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms for the administration of active macromolecules. The nanoparticles (having a nanometric size and a hydrophilic character), also called nanospheres or latex, are colloidal systems comprised of the combination of hydrophilic polymers and an active ingredient having a high molecular weight (active macromolecule, molecular weight higher than 1000 daltons). The hydrophilic polymers are the chitosan (an aminopolysaccharide) or its derivatives and polyoxyethylene or its derivatives. The association of the active macromolecule to said nanoparticles takes place in an aqueous phase without having to use organic solvents or auxiliary toxic substances. The active ingredient charge capacity of the nanoparticles is extremely high and additionally said charge is released in a controlled and time extended way. Additionally, said nanoparticles have a positive surface electric charge whose intensity may vary in relation to its composition.
A pharmaceutical composition for the administration of a bioactive macromolecule comprising hydrophilic nanoparticles consisting essentially of chitosan or a derivative thereof, and optionally a poly(oxyethylene) derivative, ionically cross-linked with a triphosphate salt, and including the bioactive macromolecule, wherein said composition was prepared in the absence of an organic solvent.
A pharmaceutical composition for the administration of a bioactive macromolecule comprising hydrophilic nanoparticles consisting of chitosan or a derivative thereof, and optionally a poly(oxyethylene) derivative, ionically cross-linked with a hydrosoluble phosphate salt, and including the bioactive macromolecule, said nanoparticles having a positive electrical charge, wherein said poly(oxyethylene) derivative is present in a percentage, with respect to the total weight of the composition, of up to 60% (w/w) and said bioactive macromolecule is present in a percentage, with respect to the total weight of the composition, of up to 60% (w/w);
Dependencies are inferred from the claim text.