Orally administrable compositions comprising cation cross-linked polysaccharide and a polymer digestible in the lower gastrointestinal tract
AssigneeGlycologic Limited
InventorsRichard Frank Tester, John Karkalas
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Abstract
Orally administrable compositions comprising cation cross-linked polysaccharides are provided. The compositions have the ability to mask the taste and delay the release of an active material included therein. A novel method for the preparation of the compositions is also provided. The cation cross-linked polysaccharide is preferably selected from alginic acid and demethylated pectin and the composition further comprises a digestible polymer, preferably chosen from starch, starch derivatives, α-glucans, peptides and polypeptides.
Claims13
A solid, erodible composition for oral administration comprising an active material and a divalent or multivalent cation cross-linked polysaccharide, the active material being uniformly distributed throughout said composition wherein the composition further comprises an amorphous, gelatinised or pre-gelatinised digestible polymer, the polysaccharide and digestible polymer together forming an interpenetrating polymeric matrix which forms a gel in the presence of a divalent or multivalent cation to form a cation cross-linked polymer matrix, wherein said active material is entangled in the polymeric matrix, wherein the digestible polymer is selected from the group consisting of starch, starch derivatives and α-glucans.
A method of forming a solid, erodible composition for oral administration comprising an active material and a divalent or multivalent cation cross-linked polysaccharide, the active material being uniformly distributed throughout said composition wherein the composition further comprises an amorphous, gelatinised or pre-gelatinised digestible polymer, the polysaccharide and digestible polymer together forming an interpenetrating polymeric matrix which forms a gel in the presence of a divalent or multivalent cation to form a cation cross-linked polymer matrix, wherein said active material is entangled in the polymeric matrix and wherein the digestible polymer is selected from the group consisting of starch, starch derivatives and α-glucans,
- said method comprising the steps of forming a solution of polysaccharide saturated with respect to the active material;
- intimately mixing a sufficient amount of the polysaccharide solution with an active material to form a paste;
- dispersing the paste in the polysaccharide solution to form a homogeneous dispersion and mixing the homogeneous dispersion with a source of divalent or multivalent cations to form a gel, the method further comprising forming a solution of the digestible polymer, intimately mixing the solution so formed with the polysaccharide solution either before or after the formation of the paste.
A kit comprising (i) a paste formed from a solution of polysaccharide and an active material, (ii) a solution of polysaccharide, (iii) an amorphous, gelatinised or pre-gelatinised digestible polymer selected from the group consisting of starch, starch derivatives and α-glucan and (iv) a source of divalent or multivalent cations.
Dependencies are inferred from the claim text.