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US 6,649,172 B2Granted
Amphipathic aldehydes and their uses as adjuvants and immunoeffectors
AssigneeCorixa Corporation
InventorDavid A. Johnson
Life of this patent
Estimating the term…
Abstract
This invention relates to novel aldehyde containing compounds and their uses as adjuvants and immunoeffectors.
Claims27
A compound, having the formula:
- wherein, R is hydrogen or —C(O)H;
- R1 is a member selected from the group consisting of hydrogen, a substituted C1-20 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, an unsubstituted C1-20 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, a saccharyl group, and a group represented by the formula —C(O)—[C(R3)(R4)]n—COOH,
- wherein each R3 and R4 independently is a member selected from the group consisting of hydrogen and a substituted C1-10 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, and an unsubstituted C1-10 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group;
- and n is a number from 1 to 5;
- R2 is a member selected from the group consisting of hydrogen, a substituted C1-20 saturated unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, an unsubstituted C1-20 saturated unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, and a group represented by the formula —(CH2)mCH(OH)(CH2)pOR5,
- wherein m and p are independently 1 or 2, and R5 is a substituted C2-20 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, or an unsubstituted C2-20 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, or a group represented by the formula
- wherein j is 1-5, and R6 and R7 are independently selected from the group consisting of hydrogen, a substituted C1-20 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group, and an unsubstituted C1-20 saturated, unsaturated or cyclic alkyl, saturated or unsaturated heteroalkyl or saturated or unsaturated heterocycloalkyl group;
- or a pharmacologically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.