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US 6,649,170 B1Granted
Adjuvant combinations for immunization composition and vaccines
AssigneeStatens Serum Institut
InventorsErik B. Lindblad, Martin J. Elhay, Peter Andersen, Lise Ostergaard Brandt
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Abstract
A kit useful for immunization is described. The kit contains an antigenic substance from a Mycobacterium and an adjuvant combination of dimethyl dioctadecyl ammonium bromide and monophosphoryl lipid A.
Claims10
An immunization combination kit comprising:
- (a) an antigenic substance from a culture of metabolizing Mycobacterium tuberculosis;
- and
- (b) an adjuvant combination consisting of dimethyl dioctadecyl ammonium bromide (DDA-Br) and monophosphoryl lipid A (MPL-A) in a ratio of from 30:1 to 4:1 by weight.
An immunization combination kit comprising:
- (a) a Mycobacterium antigen;
- and
- (b) an adjuvant combination consisting of dimethyl dioctadecyl ammonium bromide (DDA-Br) and monophosphoryl lipid A (MPL-A) in a ratio of from 30:1 to 4:1 by weight.
An improved composition for immunization comprising a Mycobacterium antigen,
- wherein said improvement consists of an adjuvanting amount of an adjuvant combination consisting of dimethyl dioctadecyl ammonium bromide (DDA-Br) and monophosphoryl lipid A (MPL-A) in a ratio of from 30:1 to 4:1 by weight.
Dependencies are inferred from the claim text.