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US 6,649,167 B2Granted
Papillomavirus truncated L1 protein and fusion protein constructs
AssigneeMediGene AG
InventorsMichael Hallek, Alexander Burger
Life of this patent
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Abstract
Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.
Claims13
A nucleic acid molecule encoding a truncated HPV L1 protein, wherein said truncated HPV L1 protein is a protein of SEQ ID NO:
- 2 except that it is lacking one or more amino acids from its carboxy terminus, amino terminus or internal region and comprises only amino acids present in naturally occurring HPV proteins.
A nucleic acid molecule encoding a fusion protein, said fusion protein comprising an amino acid sequence of a truncated first HPV L1 protein and an amino acid sequence of a second HPV protein,
- wherein said first HPV L1 protein is a protein of SEQ ID NO:
- 2 except that it is lacking one or more amino acids from its carboxy terminus, amino terminus or internal region, said second HPV protein is selected from the group consisting of E1, E2, E3, E4, E5, E6 and E7, and said fusion protein comprises only amino acids present in naturally occurring HPV proteins.
Dependencies are inferred from the claim text.