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US 6,649,165 B2Granted
Method of blocking cytotoxic activity in patients with amyotrophic lateral sclerosis using soluble FcγRIII receptors
OwnerWalter Schubertinventor
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Abstract
The present invention is directed to a method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis using an effective amount of soluble FcγRIII receptors. The soluble FcγRIII receptors of the invention are specific for immunoglobulin G of under-class 1 (IgG1) and/or 3 (IgG3).
Claims7
A method of blocking the cytotoxic activity of FcγRIII receptor-positive immune cells in a patient with amyotrophic lateral sclerosis, said method comprising the step of:
- (a) administering to said patient an effective amount of soluble FcγRIII receptors, wherein said soluble FcγRIII receptors bind to immunoglobulins in said patient to inhibit the cytotoxic activity of FcγRIII receptor-positive immune cells in said patient.
Dependencies are inferred from the claim text.