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US 6,649,164 B2Granted
Method for enhancing the functional capacity of dendritic cells
AssigneeImmunex Corporation
InventorEugene Maraskovsky
Life of this patent
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Abstract
Isolated ligands, DNAs encoding such ligands, and pharmaceutical compositions made therefrom, are disclosed. The isolated ligands can be used to enhance the functional capacity of dendritic cells.
Claims10
A method for enhancing the functional capacity of dendritic cells, said method comprising contacting the dendritic cells in vitro with a RANKL polypeptide that is capable of binding RANK, wherein said RANKL polypeptide is selected from the group consisting of:
- a) a polypeptide comprising amino acids 1-317 of SEQ ID NO:13;
- b) a polypeptide comprising amino acids 69-313 of SEQ ID NO:
- 13;
- c) a polypeptide comprising amino acids 162-313 of SEQ ID NO:
- 13
- d) a polypeptide comprising amino acids 138-317 of SEQ ID NO:13;
- e) a polypeptide comprising amino acids x to y of SEQ ID NO:
- 13, wherein x is an amino terminal amino acid between 69 and 162 of SEQ ID NO:13, and y is a carboxy terminal amino acid between 313 and 317 of SEQ ID NO:13;
- f) a polypeptide having an at least 90% amino acid sequence identity with a polypeptide comprising amino acids 162-317 of SEQ ID NO:13;
- g) a polypeptide comprising amino acids 1-294 of SEQ ID NO:11;
- h) a polypeptide comprising amino acids 48-294 of SEQ ID NO:
- 11;
- i) a polypeptide comprising amino acids 139-294 of SEQ ID NO:11;
- j) a polypeptide comprising amino acids x to y of SEQ ID NO:
- 11, wherein x is an amino terminal amino acid between 48 and 139 of SEQ ID NO:11, and y is a carboxy terminal amino acid between 290 and 294 of SEQ ID NO:11;
- and
- k) a polypeptide having an at least 90% amino acid sequence identity with a polypeptide comprising amino acids 139-294 of SEQ ID NO:11.
14 more elements
Dependencies are inferred from the claim text.