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US 6,649,163 B1Granted
Treatment and diagnosis of cancer
AssigneeCornell Research Foundation, Inc.
InventorNeil H. Bander
Life of this patent
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AssigneeCornell Research Foundation, Inc.
InventorNeil H. Bander
Estimating the term…
The present invention is directed to the use of antibodies or binding portions thereof, probes, ligands, or other biological agents which either recognize an extracellular domain of prostate specific membrane antigen or bind to and are internalized with prostate specific membrane antigen. These biological agents can be labeled and used for detection of cancerous tissues, particularly cancerous tissues proximate to or containing vascular endothelial cells, which express an extracellular domain of prostate specific membrane antigen. The labeled biological agents can also be used to detect normal, benign hyperplastic, and cancerous prostate epithelial cells or portions thereof. They also can be used alone or bound to a substance effective to ablate or kill such cells as a therapy for prostate or other cancers. Also disclosed are four hybridoma cell lines, each of which produces a monoclonal antibody recognizing extracellular domains of prostate specific membrane antigens of normal, benign hyperplastic, and cancerous prostate epithelial cells or portions thereof.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein the antibody or antigen-binding portion thereof is bound to a label.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of a E99, a J415, a J533, and a J591 monoclonal antibody, wherein the antibody or antigen-binding portion thereof is bound to a radioisotope.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to a cytotoxic drug.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to a β-emitter.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an 1399, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to a γ-emitter.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to 90Y.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to a cytotoxic drug of bacterial origin.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to a cytotoxic drug of plant origin.
A monoclonal antibody or antigen binding portion thereof which binds to an epitope of prostate specific membrane antigen (PSMA) which is also recognized by a monoclonal antibody selected from the group consisting of an E99, a J415, a J533, and a J591 monoclonal antibody, wherein said antibody or antigen binding portion thereof is bound to a cytotoxic drug of fungal origin.
Dependencies are inferred from the claim text.