Hemostatic sponge based on collagen
AssigneeBaxter Aktiengesellschaft
InventorsWolfgang Biering, Hamza Mansour, Guenther Schlag, Thomas Seelich, Edgar Scheel, Georg Habison
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Abstract
The invention relates to a hemostatic sponge based on collagen and an activator or proactivator of blood coagulation homogeneously distributed therein, which is dried and contains a water content of at least 2%, preferably in the range of 2 to 25%, more preferred 10 to 20%, and a method for producing this sponge.
Claims2
A hemostatic sponge comprising (a) collagen, (b) at least one water content stabilizer selected from the group consisting of polysaccharides and polyols and (c) at least one component selected from the group consisting of thrombin and a precursor of thrombin, wherein (i) the component is homogeneously distributed in the sponge wherein the (ii) the sponge has been lyophilized and contains a water content no less than 2%.
A method for producing a hemostatic sponge comprising collagen and at least one component selected from the group consisting of a thrombin and a precursor of thrombin, wherein (i) the component is homogeneously distributed in the sponge and (ii) the sponge is dried and contains a water content of no less than 2%, comprising
- acidifying a collagenous raw material to obtain a collagen gel,
- mixing the gel with the component to obtain a homogenous mixture, wherein the mixture is lyophilized in the presence of a substance that retains water and
- drying the mixture to a water content of no less than 2%.
Dependencies are inferred from the claim text.