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US 6,649,158 B1Granted
Methods and compositions to induce antitumor response
AssigneeCanji, Inc.
InventorDrake M. LaFace
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AssigneeCanji, Inc.
InventorDrake M. LaFace
Estimating the term…
The present invention provides compositions which are engineered to induce killing of tumor cells and concomitantly mobilize differentiate, activate and attract dendritic cells through the expression of cytokines and dendritic cell chemoattractants. The present invention invention is induces multiple stages of dendritic cell differentiation, activation and migration in vivo using gene therapy delivery systems. Moreover, this invention describes the rational design of utilizing viral vectors (preferred vector is rAd) for multiple administrations of targeted delivery to dendritic cells which can promote differentiation and activation of the transduced dendritic cells (thus augmenting in vivo stimulation of T cells, NK cells and B cells. The present invention provides a method to induce an antitumor immune response through the use of such compositions.
A recombinant adenoviral vector derived from human serotypes 2 or 5 which contains deletions in the E1a region so as to reduce binding of the E1a gene products to p300 and pRb protein family members wherein said vector expresses a dendritic cell chemoattractant.
Dependencies are inferred from the claim text.