Non-invasive localization of a light-emitting conjugate in a mammal
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsPamela R. Contag, Christopher H. Contag, David A. Benaron
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Abstract
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
Claims40
A non-invasive method for detecting a transformed, eucaryotic cell in a mammalian subject, comprising:
- administering to the subject a eucaryotic cell transformed with a heterologous gene encoding a fluorescent protein, wherein said subject comprises opaque tissue, and
- measuring photon emission through opaque tissue of said subject wherein said photon emission is mediated by fluorescent protein expressed from said heterologous gene.
Dependencies are inferred from the claim text.