Method for making HBED
AssigneeGelTex Pharmaceuticals, Inc.
InventorJames M. McKearin
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Abstract
The preparation of a mono-cationic salt of N,N′-bis(2-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid (HBED) and HBED itself is disclosed. In particular, the invention relates to the hydrolysis of the t-butyl ester of HBED with a weak acid, such as formic acid, to form HBED, and the subsequent reaction with an equimolar amount of a base to form the mono-cationic salt.
Claims4
A process for forming N,N′-bis(2-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid (HBED) which process comprises hydrolyzing a compound of formula (3) to form HBED, wherein formula (3) is:
A process of forming a monocationic salt of N,N′-bis-(2-hydroxybenzyl)-ethylenediamine-N,N′-diacetic acid (HBED), which process comprises reacting one molar equivalent of an organic or inorganic base with HBED.
Dependencies are inferred from the claim text.