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US 6,646,152 B1Granted
Method of producing 2-hydroxycarboxylic acid esters
AssigneeAbbott GmbH & Co. KG
InventorsMonika Knopp, Rolf Jansen
Life of this patent
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Abstract
A process for preparing 2-hydroxycarboxylic esters having a quaternary β-carbon atom by reaction of glycidyl esters with an organoaluminum reagent is described.
Claims7
A process for preparing 2-hydroxycarboxylic esters of the formula I
- in which
- R1 and R2 independently of one another are C1-C20-alkyl, C3-C8-cycloalkyl, C2-C20-alkenyl, C2-C20-alkynyl, C6-C10-aryl, C7-C14-aralkyl or C7-C20-alkylaryl, or R1 and R2 together with the carbon atom to which they are attached form a 5- to 8-membered ring;
- R3 is C1-C20-alkyl, C2-C20-alkenyl or C2-C20-alkynyl;
- R4 is C1-C20-alkyl, C3-C8-cycloalkyl, C2-C20-alkenyl, C2-C20-alkynyl, C6-C10-aryl, C7-C14-aralkyl or C7-C20-alkylaryl;
- which comprises reacting a glycidyl ester of the formula II
- in which R1, R2 and R4 are as defined above with an organoaluminum reagent of the formula III
- in which R3 is as defined above, X in each case independently have the meanings given for R3 or are halogen or C1-C4-alkoxy and n is from 0 to 10.
4 more elements
Dependencies are inferred from the claim text.