Polyamine analogues as therapeutic and diagnostic agents
OwnerNicolaas M. J. Vermeulin, Christine L. O'Day +3inventors
InventorsNicolaas M. J. Vermeulin, Christine L. O'Day, Heather K. Webb, Mark R. Burns, Donald E. Bergstrom
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Abstract
Novel “bispolyamine” inhibitor compounds of polyamine transport are disclosed. These compounds are useful pharmaceutical agents for treating diseases where it is desired to inhibit polyamine transport or other polyamine binding proteins, for example cancer and post-angioplasty injury. These compounds display desirable activities both for diagnostic and research assays and therapy.
Claims28
A polyamine analog or derivative, that binds to a polyamine-binding site of a molecule and/or inhibits polyamine transport, said analog or derivative having the structure
- polyamine-linker-polyamine
- wherein said polyamine comprises spermine or the N12-t-butyl carbamate of spermine and said linker comprises a 1-12 aliphatic carbon alkyl chain, an alicyclic or an aromatic moiety.
Dependencies are inferred from the claim text.