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US 6,646,012 B2Granted
Sodium channel modulators
AssigneeTheravance, Inc.
InventorsSeok-Ki Choi, Paul R. Fatheree, David C. Green, Daniel Marquess
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Abstract
The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
Claims16
A compound of formula (I):
- R1—o—R2—X—R3 (I)
- wherein:
- R1 is aryl;
- R2 is a group of formula (II):
- wherein
- A1, A2, and A20 are each independently alkylene or substituted alkylene;
- n is 0;
- R7 is hydrogen, alkyl, or substituted alkyl;
- R8 is NR10R11, wherein each of R10 and R11 is independently hydrogen, alkyl, or substituted alkyl;
- and
- X is oxygen and R3 is aryl;
- wherein any aryl of R1-R3 can optionally be substituted with from 1 to 5 substituents R8;
- wherein each R8 is independently selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, cycloalkoxy, substituted cycloalkoxy, methanediol, ethanediol, cycloalkyl, substituted alkyl, substituted alkoxy, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxy, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, and trihalomethyl;
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.