Enhancement of vascular function by modulation of endogenous nitric oxide production or activity
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJohn P. Cooke, Victor J. Dzau, Gary H. Gibbons
Life of this patent
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Abstract
Vascular function and structure is maintained or improved by long term administration of physiologically acceptable compounds which enhance the level of endogenous nitric oxide or other intermediates in the NO induced relaxation pathway in the host. Alternatively, or in combination, other compounds may be administered which provide for short term enhancement of nitric oxide, either directly or by physiological processes.
Claims45
A composition comprising L-arginine or a physiologically acceptable salt thereof in an amount sufficient to enhance nitric oxide production and grape skin extract, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, tablet, powder, or capsule.
A composition comprising L-arginine or a physiologically acceptable salt thereof and at least one additional compound associated with production of nitric oxide other than L-arginine or a physiologically acceptable salt thereof, said composition excluding other amino acids which are not precursors of nitric oxide, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, a powder, a liquid, and a capsule.
A composition comprising L-arginine or a physiologically acceptable salt thereof, at least one additional compound associated with production of nitric oxide other than L-arginine or a physiologically acceptable salt thereof and a compound that prevents the production of oxygen-derived free radicals, said composition excluding other amino acids which are not precursors of nitric oxide, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, a powder, a liquid, and a capsule.
A method, comprising administering a composition comprising L-arginine or a physiologically acceptable salt thereof and at least one additional compound associated with production of nitric oxide other than L-arginine or a physiologically acceptable salt thereof, said composition excluding other amino acids which are not precursors of nitric oxide, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, a powder, a liquid, and a capsule.
A method, comprising administering a composition comprising L-arginine or a physiologically acceptable salt thereof, at least one additional compound associated with production of nitric oxide other than L-arginine or a physiologically acceptable salt thereof and a compound that prevents the production of oxygen-derived free radicals, said composition excluding other amino acids which are not precursors of nitric oxide, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, a powder, a liquid, and a capsule.
A method, comprising administering a composition comprising L-arginine or a physiologically acceptable salt thereof in an amount sufficient to enhance nitric oxide production and grape skin extract, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, tablet, powder, or capsule.
An article of manufacture, comprising a composition comprising L-arginine or a physiologically acceptable salt thereof and at least one additional compound associated with production of nitric oxide other than L-arginine or a physiologically acceptable salt thereof, said composition excluding other amino acids which are not precursors of nitric oxide, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, a powder, a liquid, and a capsule.
An article of manufacture, comprising a composition comprising L-arginine or a physiologically acceptable salt thereof, at least one additional compound associated with production of nitric oxide other than L-arginine or a physiologically acceptable salt thereof and a compound that prevents the production of oxygen-derived free radicals, said composition excluding other amino acids which are not precursors of nitric oxide, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, a powder, a liquid, and a capsule.
An article of manufacture, comprising a composition comprising L-arginine or a physiologically acceptable salt thereof in an amount sufficient to enhance nitric oxide production and grape skin extract, wherein said composition is in a form suitable for oral administration selected from the group consisting of a pill, tablet, powder, or capsule.
Dependencies are inferred from the claim text.