Method of treating ocular inflammatory and angiogenesis-related disorders of the posterior segment of the eye using an amide derivative of flurbiprofen or ketorolac

A method of treating an ophthalmic inflammatory or angiogenesis-related disorder of the posterior segment of the eye in a patient suffering from or predisposed to such a disorder which comprises topically administering to the eye of the patient a therapeutically effective amount of a compound having the formula (I) or (II):

• wherein
• R1═H, C1-6(un)branched alkyl, (un)substituted (substitution as defined by Z below), —(CH2)n—X—(CH2)n′A;
• R2═H, C1-3 alkyl, OR3;
• R3═H, C1-3 alkyl;
• R4═H, Me—, MeO—, MeS—;
• R5═H, Me—;
• X=nothing (carbon—carbon bond), O, C═O, OC(═O), C(═O)O, C(═O)NR3, NR3C(═O), S(O)n2, CHOR3, NR3;
• X2, X2′ independently=H, F;
• n=2-6;
• n′=1-6;
• n2=0-2;
• A=H, OH, optionally (un)substituted aryl (substitution as defined by Z below), (un)substituted heterocycle (substitution as defined by Z below);
• and
• Z═H, Cl, F, Br, I, OR3, CN, OH, CF3, R4, NO2.