Antimicrobial quinolones, their compositions and uses

A compound having a structure according to Formula (I)

• wherein:
• (A)
• (1) A1 —is C(R8)—, where R8 is selected from hydrogen, halo, C1 to about C6 alkoxy, C1 to about C6 alkylthio, C1 to about C6 alkyl, C2 to about C6 alkene and alkyne;
• (2)
• (a) X is —C—, a is a double bond and b is a single bond;
• and
• (b) Y is —N(R1)—;
• (3) R1 is selected from C3 to about C6 cycloalkyl, C4 to about C6 heterocycloalkyl, C1 to about C6 alkyl, C2 to about C6 alkene, a 6-membered aryl and a 6-membered heteroaryl;
• (4) R2 is hydrogen;
• (5) R3 is selected from hydrogen and hydroxy;
• (6) R5 is selected from hydrogen, hydroxy, amino, halo, C1 to about C6 alkyl, C2 to about C6 alkene-and C1 to about C6 alkoxy;
• (7) R6 is selected from fluoro and chloro;
• (8) R7 is —Q—C(R11)(R11′)(R11″), where Q is selected from —S—, —O— and —C(R12)(R12′)—, where R12 and R12′ are each independently selected from hydrogen and fluoro;
• where R11, R11′ and R11″ are each independently selected from hydrogen, hydroxy and halo;
• and where R11 and R12 may also both be nil, such that a double bond is formed between the respective carbon atoms;
• (9) R9 and R9′ are each independently selected from hydrogen and C1 to about C15 alkyl, or R9 and R9′ join to form a heterocyclic ring containing the nitrogen atom to which they are bonded;
• and
• (10) R10 represents the moieties on the piperidine ring other than R7 and —NR9R9′, where each R10 is independently selected from hydrogen, C1 to about C6 alkyl and fluoro;
• or an optical isomer, diastereomer or enantiomer thereof;
• a pharmaceutically-acceptable salt, hydrate, or biohydrolyzable ester, amide or imide thereof.