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US 6,645,979 B2Granted
(7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine
AssigneePfizer Inc.
InventorsAnne Bruckner, Michael Butters, Paul Vincent Fish, Michael Paul Fitzgerald, Julie Ann Macrae, Trevor Jack Newbury, Richard Anthony Storey
Life of this patent
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Abstract
The invention described herein relates to a process for the preparation of (7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine (I), intermediates thereto and new forms and formulations thereof, including the zwitterion monohydrate of (I), suitable for pharmaceutical use.
Claims11
A monohydrate of formula (IA)
- or the tautomers or zwitterions thereof.
A mono-DMSO-solvate of formula (IB)
- or the tautomers or zwitterions thereof.
A carboxylate salt of the formula (IX)
- or tautomers thereof, and wherein M is Na, K or Li.
An acetate, benzoate or p-toluenesulphonate acid salt of the nitrile of formula VIII
- or tautomers thereof.
Dependencies are inferred from the claim text.