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US 6,645,973 B1Granted
Spiro(2h-1-benzopyran-2,4-piperidine)derivatives as glycine transport inhibitors
AssigneeAkzo Nobel N.V.
InventorsSamuel George Gibson, David John Miller
Life of this patent
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Abstract
The present invention relates to spiro[2H-1-benzopyran-2,4′-piperidine] derivatives having general formula (I), wherein the substituents R1, R2, X and Y are ase defined in the claims or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these spiro[2H-1-benzopyran-2,4′-piperidine] derivatives in therapy, more specifically for the treatment of CNS disorders.
Claims7
A spiro[2H-1-benzopyran-2,4′-piperidine] derivative having the formula I
- wherein
- the dotted line represents an optional bond;
- Y represents 1-4 substituents independently selected from hydrogen, halogen, (C1-6)alkyl (optionally substituted with one or more halogens), (C1-6)alkyloxy (optionally substitued with one or more halogens or with (C3-6)cycloalkyl), (C2-6)alkenyloxy, (C2-6)alkynyloxy (C3-6)cycloalkyloxy, (C6-12)aryloxy, arylalkyloxy, SR3, NR3R4, OSO2R5 and NR3SO2R4;
- or Y represents a fused (C5-6)aryl group;
- X represents 1-3 substituents independently selected from hydrogen, halogen, hydroxy, (C1-4)alkyloxy, SR3, NR3SO2R4 and (C1-4)alkyl, optionally substituted with halogen;
- R1 is hydrogen, (C1-4)alkyl or (C6-12)aryl;
- R2, R3 and R4 are independently hydrogen or (C1-4)alkyl;
- R5 is (C1-4)alkyl (optionally substituted with one or more halogens) or (C6-12)aryl (optionally substituted with (C1-4)alkyl);
- or a pharmaceutically acceptable salt thereof.
6 more elements
Dependencies are inferred from the claim text.