Quinazolinone derivatives

A method for treating urinary incontinence or pollakiuria, which comprises administering a compound given by general formula (1):

• [wherein T represents oxygen or sulfur atom, and Y represents alkyl, cycloalkyl, cycloalkylalkyl, phenyl, substituted phenyl, aralkyl, substituted aralkyl, heteroaryl or substituted heteroaryl group;
• ring W represents benzene, a 5-10 membered cycloalkene or a 5-10 membered cycloalkane ring;
• R1 and R2 represent independently hydrogen atom, lower alkyl group, halogen atom, cyano, trifluoromethyl, nitro, amino, substituted amino, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl group;
• R3 represents hydrogen atom, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, aralkyl or substituted aralkyl group;
• Z represents a group given by formula (1a) or (1b):
• {wherein A1 and A2 represent independently hydrogen atom, alkyl, substituted alkyl, cycloalkyl, saturated heterocyclic, cycloalkylalkyl, cycloalkenylalkyl, aralkyl, substituted aralkyl, heteroarylalkyl, substituted heteroarylalkyl or —CH2R4 group (wherein R4 represents alkenyl or alkynyl group), or A1 and A2 are combined together and form heterocyclic ring;
• G represents straight chain alkylene having 1-6 of the carbon number, branched alkylene having 2-8 of the carbon number, a group given by formula:
• (wherein p and m represent independently 0, 1 or 2 and D represents cycloalkane ring)} or
• {wherein n represents 0, 1 or 2, ring E represents 4-8 membered saturated heterocyclic ring containing nitrogen atom(s), and A3 represents hydrogen atom, alkyl, substituted alkyl, cycloalkyl, saturated heterocyclic, cycloalkylalkyl, cycloalkenylalkyl, aralkyl, substituted aralkyl, heteroarylalkyl, substituted heteroarylalkyl or —CH2R4 group (wherein R4 represents alkenyl or alkynyl group), or forms bicyclo ring together with ring E}], or pharmaceutically acceptable salt to a subject in need thereof.