Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase

A compound of formula:

• wherein
• Ar is a substituted or unsubstituted benzene, pyrrole, thiophene, furan, thiazole, imidazole, pyrazole, 1,2,4-triazole, pyridine, 2(1H)-pyridone, 4(1H)-pyridone, pyrazine, pyrimidine, pyridazine, isothiazole, isoxazole, oxazole, tetrazole, naphthalene, tetralin, naphthyridine, benzofuran, benzothiophene, indole, 2,3-dihydroindole, 1H-indazole, indoline, benzopyrazole, 1,3-benzodioxole, benzoxazole, purine, coumarin, chromone, quinoline, tetrahydroquinoline, isoquinoline, benzimidazole, quinazoline, pyrido[2,3-b]pyrazine, pyrido[3,4-b]pyrazine, pyrido[3,2-c]pyridazine, pyrido[3,4-b]-pyridine, 1H-pyrazole[3,4-d]pyrimidine, pteridine, 2(1H)-quinolone, 1(2H)-isoquinolone, 1,4-benzisoxazine, benzothiazole, quinoxaline, quinoline-N-oxide, isoquinoline-N-oxide, quinoxaline-N-oxide, quinazoline-N-oxide, benzoxazine, phthalazine, or cinnoline;
• X is a bond, O, S, SO, SO2, OCH2, C═C, C≡C, C═S, SCH2, NR4 or NR4CH2;
• R is independently, located at any appropriate position of Ar, hydrogen, alkyl, alkenyl, phenyl, aralkyl, aralkenyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, aralkoxy, aryloxy, acyloxy, halo, haloalkyl, nitro, cyano, amino, mono- and di-alkylamino, acylamino, carboxy, carboxyalkyl, carbalkoxy, carbaralkoxy, carbalkoxyalkyl, carbalkoxyalkenyl, aminoalkoxy, amido, mono-alkylamido, di-alkylamido, N,N-cycloalkylamido, sulfonyl, mono-alkyl sulfonyl, di-alkyl sulfonyl, sulfamoyl, mono-alkyl sulfamoyl, di-alkyl sulfamoyl, halophenyl, benzoyl, alkylthio or alkylsulfinyl;
• R4 is hydrogen, alkyl or benzyl;
• R5 is hydrogen, alkyl, alkylthio, cycloalkyl, hydroxy, alkoxy, aralkoxy, aryl, halo, haloalkyl, carboxy or carbalkoxy;
• and
• R6 and R7 are alkoxy or aralkoxy;
• or
• a pharmaceutically acceptable salt thereof, provided that:
• when R5 is hydrogen, R6 and R7 are alkoxy, and X is a bond, then Ar is other than R substituted phenyl, wherein R is hydrogen or (mono- or di-)methoxy, or R substituted pyridine, wherein R is acylamino;
• or when R5 is hydrogen, R6 and R7 are alkoxy, X is NHCH2 or NR4, and R4 is hydrogen, then Ar is other than R substituted phenyl wherein R is hydrogen;
• or when R5 is hydrogen or alkoxy, R6 and R7 are alkoxy, X is NR4CH2 and R4 is hydrogen, alkyl or benzyl, then Ar is other than quinolinyl, imidazolyl, pyrazinyl, indolyl, thiazolyl substituted by hydrogen or alkyl, or pyridinyl substituted by hydrogen, mono-alkyl or mono-hydroxy.