Chemical derivatives and their application as antitelomerase agent

Compounds corresponding to the following formula (I):

• in which:
• A represents
• an amino group of formula NR1 R2 in which R1 and R2, which are identical or different, represent hydrogen or a straight or branched alkyl group containing 1 to 4 carbon atoms,
• a group OR1 or SR1 in which R1 has the same meaning as above,
• an alkyl group containing 1 to 4 carbon atoms or a trifluoromethyl group,
• a hydrogen atom, or
• a halogen atom chosen from fluorine, chlorine, bromine or iodine
• R3 and R′3, which are identical or different, represent independently of one another a hydrogen atom or a C1-C4 alkyl group
• Ar1 and Ar2, which are identical or different, represent
• 1. when Art and Ar2 are identical:
• a quinoline motif optionally substituted with at least one group N(Ra)(Rb) in which Ra and Rb, which are identical or different, represent hydrogen, or a short-chain alkyl, alkoxy radical containing 1 to 4 carbon atoms,
• a quinoline possessing a nitrogen atom in quaternary form,
• a benzamidine except in the case where A represents diethylamine, hydrogen or an amine group, or
• a pyridine attached at the 4-position or fused with an aryl or heteroaryl group optionally substituted with a C1-C4 alkyl group
• 2. when Ar1 and Ar2 are different
• Ar1 and Ar2 both represent one of the possibilities mentioned above for Ar1 and Ar2 or
• Ar1 represents one of the above possibilities and Ar2 represents
• a phenyl ring optionally substituted at the meta or para position with a halogen group, C1-C4 alkoxy group, cyano group, carbonylamino group optionally substituted with one or more C1-C4 alkyl groups, guanyl groups, C1-C4 alkylthio groups, amino groups, C1-C4 alkylamino groups, C1-C4 dialkylamino groups for each alkyl group, nitro group, alkyleneamino group, or alkenyleneamino group
• a mono- or bi- or tricyclic hetero-cyclic ring comprising 0 to 2 heteroatoms per ring provided that at least one heteroatom is present in at least one ring optionally substituted with one or more C1-C4 alkyl groups or with alkylene or alkenylene groups
• or one or its salts
• excluding 2-amino-bis-4,6-[(4′-amino-6′-quinaldinyl)amino]triazine dihydrochloride and 2-amino-bis-4,6-(p-amidinoanilino) triazine dihydrochloride;
• and
• with the proviso that the compound is not (a) benzenecarboximidamide,4-[4-chloro-6-(phenylamino)-1,3,5-triazin-2-yl]amino, or (b) 1,3,5-triazine-2,4,6-triamine,N,N′-bis(4-amino-2-methyl-6- quinolinyl)-trihydrochloride.