Antifungal sordaricin derivatives

A compound of formula (I)

• and physiologically acceptable salts
• wherein:
• R1 is selected from the group consisting of
• C1-6 straight or branched chain alkyl,
• C1-6 straight or branched chain alkoxy, optionally substituted phenoxy,
• C3-6 straight or branched chain, alkenyloxy, optionally substituted by 1 or 2 halogen atoms, and
• C1-4 straight or branched alkoxy substituted by an optionally substituted phenyl group,
• C3-8 straight or branched chain alkynyl,
• C3-6 straight or branched chain alkenyl, optionally substituted by C1-4 alkoxy or 1 or 2 halogen atoms,
• optionally substituted phenyl,
• optionally substituted C3-7 cycloalkyl,
• optionally substituted C5-7 cycloalkenyl,
• C2-4 straight or branched chain alkyl substituted by a group selected from the group consisting of C1-4 alkoxy, C1-4 alkyl thio and halogen,
• C1-4 straight or branched chain alkyl substituted by a group selected from the group consisting of C1-4 alkoxycarbonyl, arylalkyloxycarbonyl, aryloxycarbonyl, propadienyl, cyano, optionally substituted C3-7 cycloalkyl, optionally substituted 5 or 6 membered heteroaryl, and 1 or 2 optionally substituted phenyl groups,
• and methyl substituted by C1-6 alkanoyl, optionally substituted benzoyl;
• R2 is a group selected from hydrogen, C1-6 straight or branched chain alkyl, C3-6 straight or branched chain alkenyl, optionally substituted phenyl and C1-4 alkyl substituted with a group selected from C1-4 alkoxy hydroxy, acyloxy, alkoxycarbonyl and aryloxycarbonyl;
• R3 is a group selected from formyl or cyano;
• R is phthalidyl, (2-oxo-5-methyl-1,3-dioxoblen-4-yl) methyl or the group CHR4OCO(O)pR5 wherein R4 is hydrogen or C1-4 alkyl, p is zero or 1 and wherein R5 is C1-6 alkyl, C5-8 cycloalkyl, optionally substituted by C1-3 alkyl or carboxyl, C1-4 alkyl substituted by C1-3 alkoxy or carboxyl, C1-6 alkyl substituted by one or more groups selected from amino, C1-4 alkylamino di(C1-4 alkyl)amino or carboxyl, phenyl, optionally substituted by carboxyl or aminoalkyl, a C1-4 alkylaminoalkyl or
• di(C1-4 alkyl)aminoalkyl, or R5 is a 5-8 membered heterocyclic group containing 1 or 2 heteroatoms selected from oxygen or nitrogen.