Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
AssigneeChitogenics, Inc.
InventorsClive M. Elson, Timothy D. G. Lee
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Abstract
The present invention relates to a method of inhibiting cellular and protein attachment to substrates by applying a composition containing an effective amount of adherent N,O-carboxymethylchitosan to a substrate with such that cellular and protein attachment are prevented or greatly reduced.
Claims4
A method of inhibiting fibroblast attachment in an Ex vivo cell-based product selected from the group consisting of cell cultures, blood and plasma in contact with a solid support comprising contacting said cell based product with a solid support having a N,O-carboxymethylchitosan coating, said N,O-carboxymethylchitosan coating being selected from the group consisting of solutions, hydrogels, pastes, rehydratable films, creams, foams, and sponges of N,O-carboxymethylchitosan which is adherent to freshly excised tissue with a force of at least 100 dynes/cm2, said coating providing inhibition of attachment of fibroblasts to said solid support.
Dependencies are inferred from the claim text.