Substituted β-alanine derivatives as cell adhesion inhibitors

A compound having the formula Ib:

• wherein
• R1 is phenyl optionally substituted with one or two groups selected from halogen, O—C1-3alkyl, and trifluoromethyl;
• R2 is H or methyl;
• B is O, S, a bond or CH2;
• A is —C—;
• Y is —SO2;
• R4, R5, R6 are independently selected from H, C1-3 alkyl and halogen;
• R7 is hydrogen;
• R8 is aryl, heteroaryl, aryl-aryl, aryl-heteroaryl or heteroaryl-aryl wherein aryl and heteroaryl are optionally substituted with one to three groups selected from halogen, CN, ORd, O(CO)Re, C1-5alkyl optionally substituted with one or two groups selected from Rc, CF3, and OC(O)NRdRe;
• Rc is
• p31) halogen,
• 2) CN,
• 3) NH(C1-5alkyl),
• 4) N(C1-5alkyl)2,
• 5) amino,
• 6) carboxy,
• 7) C1-4alkyl,
• 8) C1-4alkoxy,
• 9) aryl,
• 10) aryl C1-4alkyl, or
• 11) aryloxy;
• Rd and Re are independently selected from hydrogen, C1-10alkyl, C2-10alkenyl, C2-10alkynyl, Cy and Cy-C1-10alkyl, wherein alkyl, alkenyl, alkynyl and Cy is optionally substituted with one to four substituents independently selected from Rc;
• or
• Rd and Re together with the atoms to which they are attached form a heterocyclic ring of 5 to 7 members containing 0-2 additional heteroatoms independently selected from oxygen, sulfur and nitrogen;
• Cy is cycloalkyl, heterocyclyl, aryl or heteroaryl.