Protection against ischemia and reperfusion injury
AssigneesZymoGenetics, Inc., University of Kentucky Research Foundation
InventorsPeter R. Oeltgen, Paul D. Bishop, Mark S. Kindy, Juan A. Sanchez
Life of this patent
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Abstract
A compound and method for using compound-D SEQ ID NO:1 to reduce injury associated with ischemia and reperfusion of mammalian organs such as the heart. The compound may be administered as part of a preconditioning strategy which reduces the extent of injury and improves organ function following cessation and restoration of blood flow. The compound may be used in preparation for planned ischemia or in a prophylactic manner in anticipation of further ischemic events.
Claims12
A method of protecting against ischemia and reperfusion injury in a human comprising administering an effective amount of compound-D (SEQ ID NO:1) to the human in a pharmaceutically acceptable formulation.
A method for reducing effects of ischemia in a human comprising administering an effective amount of compound-D (SEQ ID NO:1) in a pharmaceutically acceptable carrier to the human.
The method of claim 19 wherein compound-D SEQ ID NO:1 is administered prior to ischemia.
Dependencies are inferred from the claim text.