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US 6,645,935 B2Granted
Synthesis of glycoconjugates of the lewis Y epitope and uses thereof
AssigneesSloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York
InventorsSamuel J. Danishefsky, Victor Behar, Kenneth O. Lloyd
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Abstract
The present invention provides a method of synthesizing an allyl pentasaccharide having the structure: as well as related oligosaccharide ceramides and other glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer cells in an adjuvant therapy therefor, and in a method for preventing recurrence of epithelial cancer.
Claims21
A compound having the structure:
- wherein n is 0, 1, 2, 3, or 4, conjugated to a protein carrier at its allyl group.
A compound having the structure:
- conjugated to a protein carrier at its allyl group.
Dependencies are inferred from the claim text.