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US 6,645,777 B1Granted
Tapered tubular optical waveguide probe for magnetic focusing immunosensors
AssigneeThe Board of Governors for Higher Education the State of Rhode Island and Providence Plantation.
InventorsStephen Letcher, He Cao, Hazem Baqaen, A. Garth Rand
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Abstract
A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end to configure to focus paramagnetic microspheres attached to antigen/antibody/optically labeled antibody complexes in the field of view. The proximal end is polished to form an aperture.
Claims10
A waveguide probe for the detection of pathogens in a sample comprising:
- a laser;
- a first tube;
- a second tube, the tubes converging at a point to define a proximal end;
- a magnet positioned in the proximal end configured to focus paramagnetic microspheres attached to antigen/antibody/optically labeled antibody complexes in a field of view, the proximal end shaped to form a receiving aperture;
- means to transmit an excitation signal from the laser through the first tube;
- and
- means for detecting and measuring fluorescent signals transmitted through the second tube.
4 more elements
Dependencies are inferred from the claim text.