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US 6,645,742 B2Granted
Purifying process for phosphatidylserine
AssigneeChemi S.p.A.
InventorsLorenzo De Ferra, Pietro Massardo
Life of this patent
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Abstract
The present invention relates to a purifying process for phosphatidylserine, the latter being prepared by trans-phosphatidylation of phosphatidylcholine with serine in presence of the enzyme D-phospholipase and containing as impurities hydrophilic compounds, proteins and inorganic salts.
Claims32
Purifying process for phosphatidylserine having formula (I)
- where R1 and R2, identical or different, are a C10-C30 acyl group;
- X is OH or OM, where M is chosen from the group of alkali metals, alkaline-earth metals, ammonium and alkyl ammonium,
- and where the serine portion is in D, L or racemic form, comprising the extraction of said phosphatidylserines from a solution in a hydrocarbon solvent chosen among aromatic and aliphatic hydrocarbon solvents, with a mixture of water and an alcohol solvent.
A purifying process for phosphatidylserine having formula (I)
- where R1 and R2, identical or different, are C10-C30 acyl groups;
- X is OH or OM, where M is chosen from the group consisting of alkali-earth metals, ammonium and alkyl ammonium;
- and
- where the serine portion is in D, L or racemic form;
- which comprises stirring said phosphatidylserine in a mixture comprising water, an alcohol solvent, and a hydrocarbon solvent selected from the group consisting of aromatic and aliphatic hydrocarbon solvents.
2 more elements
Dependencies are inferred from the claim text.