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US 6,645,529 B2Granted
Instant granules and process for their formulation
AssigneeDr. Gergely & Co.
InventorsGerhard Gergely, Irmgard Gergely
Life of this patent
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AssigneeDr. Gergely & Co.
InventorsGerhard Gergely, Irmgard Gergely
Estimating the term…
The pharmaceutical formulation according to the invention is in the form of instant granules, in which the surface of the particles of at least two different soluble carrier materials is covered or coated with at least one layer which contains -of from 50 to 120, preferably from about 60 to about 100, parts by weight of active substance per 100 parts by weight of carrier material -of at least one, preferably insoluble or slightly soluble, active substance, such as amino acids or antioxidants. A first carrier material constitutes from about 50 to about 80% by weight of the total carrier material and is selected from carrier materials having a bulk density of between 58 and 100, preferably between 63 and 90 g/100 ml, while the second carrier material is selected from carrier materials having a bulk density of between 30 to 55, preferably between 33 and 50 g/100 ml.
Pharmaceutical formulation in the form of granules capable of suspension in water, in which the surface of the particles of at least two different soluble carrier materials is covered or coated with at least one layer which contains at least one active substance, characterized in that said active substance is present in solid pulverized form, and wherein some of said active substance is attached by a binder to a first carrier material that is selected from carrier materials having a bulk density of between 58 and 100, and wherein some of said active substance is attached to a tacky layer of a second carrier material that is selected from carrier materials having a bulk density of between 30 to 55.
Dependencies are inferred from the claim text.