Polypeptide expressed in the horny layer of epidermis and use thereof

A method for treating the thinning of the epidermis, comprising administering to the skin of a subject in need of treatment an effective amount of a composition comprising, in a physiologically acceptable medium, one or more purified natural or synthetic polypeptide(s), wherein each of said polypeptide(s) comprise the amino acid sequence of SEQ ID NO:

• 1.

A method for treating trophic skin disorders or trophic skin disorders following cicatrization disorders comprising administering an effective amount of a composition comprising, in a physiologically acceptable medium, one or more purified natural or synthetic polypeptide(s), wherein each of said polypeptide(s) comprise the amino acid sequence of SEQ ID NO:

• 1.

A cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic polypeptide comprising the amino acid sequence of SEQ ID NO:

• 1.

A composition comprising, in a physiologically acceptable medium, a nucleic acid molecule comprising the coding nucleotide sequence of SEQ ID NO:

• 2.

A method for strengthening intercorneocyte cohesion, comprising administering to the skin of a subject in need of intercorneocyte cohesion strengthening an effective amount of a composition comprising, in a physiologically acceptable medium, one or more purified natural or synthetic polypeptide(s), wherein each of said polypeptide(s) comprise the amino acid sequence of SEQ ID NO:

• 1.

A method of promoting desquamation to the skin of a subject in need of desquamation promotion, comprising administering an effective amount of the composition in a physiologically acceptable medium, one or more purified natural or synthetic polypeptide(s), wherein each of said polypeptide(s) comprise the amino acid sequence of SEQ ID NO:1.