Stable L-ascorbic acid composition
OwnerJivn-Ren Cheninventor
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Abstract
A stable composition including a water-sensitive pharmacologically active agent, such as an enzyme, an antibiotic or a vitamin, a hydrophilic non-polar primary solvent, an optional hydrophilic non-polar secondary solvent and optional pharmaceutical or cosmetic adjuvants to enhance appearance for topical use. Where the water-sensitive or water-degradable component is L-Ascorbic acid and the principal solvent is N-methyl-2-pyrrolidone (“NMP”) the composition is stable for many months at a concentration of L-Ascorbic acid of up to about 40 % w/v. This composition using NMP as a solvent and enhancer of skin penetration together with appropriate adjuvants is useful for preparing dermatological topical dosage for cosmetic and therapeutic purposes.
Claims8
A topical, water-free composition comprising, based on the weight by volume of the composition:
- from 1% to about 35% of a pharmacologically active agent consisting of L-ascorbic acid;
- N-methyl-2-pyrrolidone;
- and
- wherein the topical, water-free composition is in the form of a solution, a gel, a cream, an ointment, or a lotion, and wherein the L-ascorbic acid in the composition does not lose more than 5% of its potency within two months at ambient storage conditions.
A topical, water-free composition comprising, based on the total weight of the composition:
- from 1% to about 35% of a pharmacologically active agent consisting of L-ascorbic acid;
- from about 45% to about 94% of N-methyl-2-pyrrolidone;
- from about 5% to about 20% of glycerin;
- and
- wherein the topical, water-free composition is in the form of a solution, a gel, a cream, an ointment, or a lotion, and wherein the L-ascorbic acid in the composition does not lose more than 5% of its potency within two months at ambient storage conditions.
A method for stabilizing from 1% to about 35%, based on weight by volume, of a pharmacologically active agent consisting of L-ascorbic acid in the absence of water to give a solution, a gel, a cream, an ointment, or a lotion of the L-ascorbic acid, comprising:
- dissolving the pharmacologically active agent consisting of L-ascorbic acid in a hydrophilic non-polar primary solvent selected from the group consisting of N-methyl-2-pyrrolidone, caprylyl pyrrolidone, lauryl pyrrolidone, and a mixture thereof, wherein the L-ascorbic acid in the gel, the cream, the ointment, or the lotion does not lose more than 5% of its potency within two months at ambient storage conditions.
A topical, water-free composition comprising, based on the weight by volume of the topical:
- from 1% to about 40% of a pharmacologically active agent consisting of L-ascorbic acid;
- and
- a hydrophilic non-polar primary solvent, the hydrophilic non-polar primary solvent comprising N-methyl-2-pyrrolidone, caprylyl pyrrolidone, lauryl pyrrolidone, or a mixture thereof, wherein the topical, water-free composition is in the form of a solution, a gel, a cream, an ointment, or a lotion, and wherein the L-ascorbic acid in the composition does not lose more than 5% of its potency within two months at ambient storage conditions.
Dependencies are inferred from the claim text.